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KMID : 1143420210140110597
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Public Health Weekly Report
2021 Volume.14 No. 11 p.597 ~ p.606
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Genotype analysis of severe fever with thrombocytopenia syndrome virus detected in patients
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Choi Eun-Ji
Lim A-Ram
Kang Hae-Ji
Han Myung-Guk
Kim Chi-Kyeong
Wang Eun-Byeol
Choi Woo-Young
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Abstract
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Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne disease caused by the SFTS virus (SFTSV). Since the first SFTS patient in Korea was reported in 2013, approximately 200 cases of SFTS have been reported annually for the past three years. In this study, the genotypes of 352 SFTSVs detected from SFTS suspected patient samples over the past three years (2017-2019) were analyzed to compare the genotypic epidemic patterns and distribution status of genotypes by
region. This study further analyzed the annual and regional incidence of SFTS. As a result of analysis, six different
genotypes of SFTSV were identified.
Of the 352 SFTSV, the majority observed in genotype B accounted for 77.6% of the total genotypes identified, followed by
genotype D (10.5%) and genotype A (6.3%). The detection rates of genotypes C, E and F were low; less than 10 cases over three years. For three consecutive years, genotype A occurred repeatedly in patients residing in Gyeonggi Province and Gangwon Province, and genotype D and E were persistently detected in patients residing in Chungnam Province. As a result of comparing the incidence rate per 100,000 people by region, Jeju Province and Gangwon Province showed higher rates of occurrence than other regions. In this study, there was a limit to the specifying the regional distribution pattern of the SFTSV genotype based only on the residential area information of each patient. However, theses results can be used as strategic data for the selection of genotype candidates for SFTS vaccine design and for the identification of diseases
occurrence patterns associated with genotype changes by continuously monitoring in the genotype distribution of
domestic SFTSV to control SFTS infectious diseases.
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KEYWORD
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Severe fever with thrombocytopenia syndrome (SFTS), SFTS virus, Genotype, Tick, Platelet
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